The Hematopoietic Microenvironment

Extracellular vesicles in the hematopoietic microenvironment

Self-renewal and differentiation are defining characteristics of hematopoietic stem and progenitor cells, and their balanced regulation is central to lifelong function of both blood and immune systems. In addition to cell-intrinsic programs, hematopoietic stem and progenitor cell fate decisions are subject to extrinsic cues from within the bone marrow microenvironment and systemically. Yet, man...

XWH - 11 - 1 - 0732 TITLE : Redefining the Hematopoietic Microenvironment PRINCIPAL

XWH - 11 - 1 - 0732 TITLE : Redefining the Hematopoietic Microenvironment

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Expression of human bone-related proteins in the hematopoietic microenvironment.

Given the intimate relationship between bone and bone marrow, we hypothesized that the human bone marrow may function as a source (or reservoir) of bone-forming progenitor cells. We observed a population of cells within the bone marrow which produce bone-specific or bone-related proteins. The production of these proteins was developmentally regulated in human long-term bone marrow cell cultures...

The Positive Effects of Ginsenoside Rg1 upon the Hematopoietic Microenvironment in a D-Galactose-Induced Aged Rat Model Running title: Ginsenoside Rg1 Affects Hematopoietic Microenvironment of Aged Rats

Background: Ginsenoside Rg1 (Rg1) is one of the most active ingredients in Panax ginseng and has been proven to have anti-oxidative and anti-aging properties. However, there have been few reports concerning the anti-aging effects of Rg1 on the hematopoietic microenvironment and bone marrow stem cells (BMSCs). Methods: Thirty Sprague-Dawley rats were randomly divided into four groups (control, D...